Marina Silalahi


Crinum asiaticum is a type of Amarallydaceae has been long used as a traditional medicine. The purpose of this article is to explain the relationship between the use of C. asiaticum as a traditional medicine and its bioactivity. The method used in writing the article is a literature review on some research published online using the keyword C. asiaticum, uses of C. asiaticum and bioactivities of C. asiaticum. The results obtained were then synthesized to explain the utilization and bioactivity of C. asiaticum. The traditional medicine of C. asiaticum is used to treat fever, treat fractures, sprains, inflammation and treat back pain. C. asiaticum has bioactivity as an antioxidant, antidiabetic mellitus, antimicrobial, anti-cancer, anti-inflammatory, analgesic and anti-urolytic. Licorin, crinamin and 6-hydroxycrinamine are compounds that are responsible for anti-cancer, so it is potential to be developed as an alternative anti-cancer because they are easily found in the environment.


Crinum asiaticum, anti-cancer, crinamin, licorine

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Arai, M.A., Akamine, R., Sadhu, S.K., Ahmed, F. and Ishibashi, M. 2015. Hedgehog/GLI-mediated transcriptional activity inhibitors from Crinum asiaticum. J Nat Med 69: 538-542.

Arista, Y.N., Kumesan, Yamlean, P.V.Y. and Supriati, H.S. 2013. Formulasi dan uji aktivitas gel antijerawat ekstrak umbi bakung (Crinum asiaticum L.) terhadap bakteri Staphylococcus aureus secara in vitro. Pharmacon Jurnal Ilmiah Farmasi 2(2):

Endo, Y., Sugiura, Y., Funasaki, M., Kagechika, H., Ishibashi, M. and Ohsaki, A. 2019. Two new alkaloids from Crinum asiaticum var. japonicum. Journal of Natural Medicines 73: 648-652.

Hariyadi, B. and Ticktin, T. 2012. Uras: medicinal and ritual plants of Serampas, Jambi Indonesia. Ethnobotany Research & Applications 10:133-149.

Hyun, J.H., Kang, J.I., Kim, S.C., Kim, E., Kang, J.H., Kwon, J.M., Park, D.B., Lee, Y.J., Yoo, E.S. and Kang, H.Y. 2008. The effects of Crinum asiaticum on the apoptosis induction and the reversal of multidrug resistance in HL-60/MX. Toxicol. Res. 24(1): 29-36.

Indradevi, S., Ilavenil, S., Kaleeswaran, B., Srigopalram, S., and Ravikumar, S. 2012. Ethanolic extract of Crinum asiaticum attenuates hyperglycemia-mediated oxidative stress and protects hepatocytes in alloxan induced experimental diabetic rats. Journal of King Saud University-Science 24: 171-177.

Kim, Y.H., Park, E.J., Park, M.H., Badarch, U., Woldemichael, G.M. and Beutler, J.H. 2006. Crinamine from Crinum asiaticum var. japonicum inhibits hypoxia inducible factor-1 activity but not activity of hypoxia inducible factor-2. Biol. Pharm. Bull. 29(10): 2140-2142.

Lim, H.S., Kim, Y., Kim, Y.J., Sohn, E., Kim, J.H. and Jeong, S.J. 2020. The effects of Crinum asiaticum var. japonicum Baker seeds on neuroprotection and antineuroinflammation in neuronal cell lines. Natural Product Communications 15(10): 1-10.

Min, B.S., Gao, J.J., Nakamura, N., Kim, Y.H. and Hattori, M. 2001. Cytotoxic alkaloids and a flavan from the bulbs of Crinum asiaticum var. Japonicum. Chem. Pharm. Bull. 49(9) 1217-1219.

Pandey, P.K., Kass, P.H., Soupir, M.L., Biswas, S. and Singh, V.P. 2014. Contamination of water resources by pathogenic bacteria. AMB Express 4(51): 1-16.

Rahman, M.A., Sharmin, R., Uddin, M.N., Rana, M.S. and Ahmed, N.U. 2011a. Antibacterial, antioxidant and cytotoxic properties of Crinum asiaticum bulb extract. Microbiol 28(1): 1-5.

Rahman, M.A., Sharmin, R., Uddin, M.Z., Mahbubuzzaman, Rana, S. and Ahmed, N.U. 2011b. Antinociceptive and antiinflammatory effect of Crinum asiaticum bulb extract. Asian J Pharm Clin Res 4(3): 3437.

Rahman, M.A., Hossain, S.M.A., Ahmed, N.U. and Islam, M.S. 2013. Analgesic and anti-inflammatory effects of Crinum asiaticum leaf alcoholic extract in animal models. African Journal of Biotechnology 12(2): 212-218.

Riris, I.D., Simorangkir, M. and Silalahi, A. 2018. Antioxidant, toxicity and antibacterial properties of ompu-ompu (Crinum asiaticum L.) ethanol extract. Rasayan J. Chem 11(3): 1229-1235

Silalahi, M. 2014. The ethnomedicine of the medicinal plants in sub-ethnic Batak, North Sumatra and the conservation perspective. Dissertation. Indonesia Universitas Indonesia.

Silalahi, M., Nisyawati, Walujo, E.B. and Supriatna, J. 2015. Local knowledge of medicinal plants in sub-ethnic Batak Simalungun of North Sumatra, Indonesia. Biodiversitas 16(1): 44-54.

Silalahi, M., Purba, E.C. and Mustaqim, W.A. 2018. Tumbuhan obat Sumatera Utara. Jilid I. Mononkotiledon, UKI Press, Jakarta.

Su, X.Z. and Miller, L.H. 2015. The discovery of artemisinin and nobel prize in physiology or medicine. Sci China Life Sci. 58(11): 1175-1179.

Supiandi, M.I., Mahanal, S., Zubaidah, S., Julung, H. and Ege, B. 2019. Ethnobotany of traditional medicinal plants used by Dayak Desa Community in Sintang, West Kalimantan, Indonesia. Biodiversitas 20(5): 1264-1270.

Sura, S. and Solleti, V.S.K. 2020. Assessment of antiurolithiatic potentials of Crinum asiaticum bulbs by in vitro and in vivo approaches. J Young Pharm 12(2) Suppl: s76-s81.

Surain, P. and Aneja, K.R. 2014. Anticandidal potential of Crinum asiaticum leaves extract against selected oral and vaginal Candida pathogens. Journal of Innovative Biology 1(1): 027-030.

Uddin, N.Z., Emran, T.B., Nath, A.K., Jenny, A., Dutta, M., Morshed, MM and Kawsar, M.H. 2012. Anti-inflammatory and antioxidant activity of leaf extract of Crinum asiaticum. Journal of Pharmacy Research 5(12): 1-6.

Wiederhold, N.P., Najvar, L.K., Fothergill, A.W., McCarthy, D.I., Bocanegra, R., Olivo, M., Kirkpatrick, W.R., Everson, M.P., Duncanson, F.P. and Patterson, T.F. 2015. The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant Candida albicans. Antimicrobial Agents and Chemotherapy 59(1): 690-692.

Yuso, S.M., Asmawi, M.Z., Abdul Majid, A.M.S., Basheer, M.K.A., Mohamed, S.K., Asif, M., Jafari, S.F. and Baharetha, H.M. 2017. Anti-angiogenesis as a possible mechanism of action for anti-tumour (potential anti-cancer) activity of Crinum asiaticum leaf methanol extract. Angiotherapy 1(1): 012-017.


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